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The Phase 2 trial reference point The Phase 2 retatrutide trial (Jastreboff et al., New England Journal of Medicine 2023) enrolled 338 adults across placebo and retatrutide arms at 1, 4, 8, and 12 mg weekly

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So its important to pay attention to any symptoms -- which can grow slowly or pop up more quickly -- and to alert your doctor

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Consider primary brain tumors as an example

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