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A number of approaches targeting deficient GCase activity in GBA-PD have reached the stage of clinical phase 2/3 trials including orally active GCase chaperones to enhance enzymatic activity, substrate reduction therapies modelling current treatment of Gauchers disease and GBA gene therapy (Table 5)

Ethical approval The Ethics Committee of Qilu Hospital, Qilu Hospital, Cheeloo College of Medicine, Shandong University, approved the study in this manuscript

Important by-products of this plant include anhydro-vinblastine, vindoline, catharanthine, ajmalicine, and serpentine

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The presence of dietary fat triggers bile release, which helps emulsify and absorb fat-soluble nutrients like omega 3 fatty acids

When the immune system is underactive, thymosin alpha-1 enhances immune function