[Abstract]2023 Aug:64:102786
SmitsMMTonneijckLMuskietMHHoekstraTKramerMHDiamantMet al
2014 STIER, H., VOS, E., KENLEY, D
When to contact your provider about dosing questions Contact your provider within 24 hours if: You drew or injected the wrong dose and the error is clinically significant: Injected 2x or more of the prescribed dose (e.g., 48 units instead of 24 units) Injected at the wrong frequency (e.g., two doses in one week instead of one) Missed two consecutive weekly doses You experience symptoms suggesting overdose: Persistent nausea or vomiting lasting more than 24 hours Inability to keep down fluids (signs of dehydration: dark urine, dizziness, dry mouth, confusion) Severe abdominal pain, especially if localized to the upper abdomen and radiating to the back (possible pancreatitis) Severe diarrhea (more than 6 watery stools in 24 hours) You have signs of an allergic reaction: Hives, rash, or itching that worsens over hours Swelling of the face, lips, tongue, or throat Difficulty breathing or swallowing Rapid heartbeat with dizziness For minor dose errors (e.g., 25 units instead of 24 units, or accidentally injecting 23 units), no immediate action is needed
Results often begin to appear after several sessions, with progressive improvement in skin tone, clarity, and texture over time
This landmark report demonstrates rapid-onset antidepressant effects of ketamine dependent on the activation of the mTOR pathway and increased number and function of new spine synapses in the PFC of rats
