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The company failed to provide adequate warnings about this risk, which allegedly led to a lack of awareness in the medical community and potentially affected prescribing decisions

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NNT activity contributes to 45% of the total NADPH in mitochondrial pool, indicating a significant role of NNT for NADPH pool maintenance, 111 and NADPH obtained by NNT is also used for the reductive carboxylation of -KG to isocitrate mediated by IDH2

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