Yoshikawa T, Ide T, Shimano H, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Yatoh S, Kitamine T, Okazaki H, Tamura Y, Sekiya M, Takahashi A, Hasty AH, Sato R, Sone H, Osuga J, Ishibashi S, Yamada N (2003) Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism
In vivo and in vitro results showed that Vit C treatment enhanced pancreatic acinar cell apoptosis, as evidenced by increased expression of Bcl-2, Bcl-XL, and MCL-1 and decreased expression of the apoptosis regulator Bax
PMID: 32294214
N-acetylcysteine (NAC) is a glutathione precursor that raises hepatic glutathione over days to weeks with chronic use, but acute dosing (6001,200mg) for hangover shows no benefit in randomised controlled trials
Larger and longer trials are needed to further assess the efficacy and safety of tirzepatide for the treatment of MASH
Study 2: Dorr 1996, pilot clinical tanning study Citation: Dorr R.T., Lines R., Levine N., et al
