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GCs are used more consistently in Western settings, whereas Asian studies either excluded patients on GC or used heterogeneous regimens, potentially exaggerating the benefit of G-CSF

348 The role of the UPS in NDDs The ubiquitinproteasome system (UPS) represents a highly coordinated protein quality-control network responsible for selectively tagging, recognizing, and degrading damaged, misfolded, or excess proteins through ubiquitination