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Replenishing it through IV therapy is generally safe and well tolerated

One inconsistency is that in vivo morphine-induced antinociception is increased in the knockout animals but, if anything, MOR coupling to GIRK (Dang et al., 2011

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Hyperpigmentation was observed when this compound got oxidized and inactivated by factors such as heat, radiation and inflammation with consequent loss of the inhibitory effect on tyrosinase

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