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Alcohol can independently cause both, especially in larger amounts

A review published in *Nutrients* (2019) discussed the role of nutrients involved in supporting glutathione, highlighting its importance in reducing oxidative stress, metabolic detoxification, and regulating immune function

Dose Requirements and Consistency: Because of first-pass metabolism and enzymatic breakdown, oral forms may require higher nominal dosing or specialized carriers to approach comparable exposure to injectables

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Contraindications and Precautions: AOD-9604 should be avoided or used only under close medical supervision in individuals with active malignancy or history of cancer, as the effects of the peptide on tumor growth have not been adequately studied

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