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While data specific to GLP-1 RA discontinuation remain limited, a large-scale prospective study on weight cycling (mean age 63.6 years, at high risk of T2DM) reported that weight regain was typically characterized by an adverse shift in body composition, with FM returning to baseline levels while FFM declined by 1.50 kg (95% CI 0.662.35)

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Cardiovascular outcome trials in obesity: A review

Inflammatory cytokines such as IL-6 and TNF- have been implicated in muscle catabolism and impaired regeneration

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Staying well hydrated helps support cognitive function and may reduce symptoms