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Caverzan A, Passaia G, Rosa SB, Ribeiro CW, Lazzarotto F, Margis-Pinheiro M

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These investigations are conducted strictly within controlled laboratory environments

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However, the measurement of the ratio of [GSH]:[GSSG] in an intracellular organelle is fraught with technical difficulties

Moreover, these leukocyte-endothelial cell interactions can also directly contribute to increase BBB permeability by releasing reactive oxygen species, cytokines, and other mediators of barrier disruption [60]