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The ALOX family can mediate PUFAs peroxidation to generate AA/AdA-PE-OOHs, thereby triggering ferroptosis (Lei et al., 2019)

Iron ions in the form of Fe 2+ or Fe 3+ reside in cells i n vivo, and iron homeostasis maintains the relatively stable content of these ions through transferrin receptor 1 (TFR1)-regulated iron transport, ferroportin 1 (FPN1)-mediated iron output storage, and ferritin-regulated iron storage (Fig

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7 Investigation of GPX4 degradation mechanism after treatment with ferroptosis inducers

Data Availability Statement Data sharing is not applicable to this article as no new data were created or analyzed in this study.