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doi: 10.3389/fphar.2019.01102 Received 07 May 2019 Accepted 26 August 2019 Published 20 September 2019 Volume 10 - 2019 Edited by Deslypere Jean Paul, Besins Healthcare, Thailand Reviewed by Pooja Dhupkar, University of Texas MD Anderson Cancer Center, United States

Xia H, Cao Z, Xie X, Zhang X, Chen JY-C, Wang H, et al

Biol 29 , 15881600 (2022)

Animal research typically uses weight-based scaling around 10 g/kg, but direct translation of that number to human dosing has never been validated in clinical research

It is part of the endocrine system and helps regulate circadian rhythms through the production of melatonin, a hormone involved in sleep timing and biological clock regulation (read more on melatonin in our previous blog post)

The scientists tried FOXO4-DRI on naturally aged mice AND GOT THE EXACT SAME OUTCOME