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The possible mechanisms of their protective effects may be associated with the decrease of p16-, p21 expressing cells and the downregulation of senescence-associated secretory phenotype (including the expression of pro-inflammatory cytokines IL-6, IL-1, and MMP-9) ( 4.5 Other renal disorders Dietary intake of the flavonoid quercetin has been proven effective in lowering blood pressure and restoring endothelial dysfunction in animal models of hypertension

This research was supported by the Department of Defense (W81XWH-18-1-0206), The Hartwell Foundation, the Schwartz Research Fund and the National Institute of Diabetes and Digestive and Kidney Diseasesfunded Integrated Islet Distribution Program Award Initiative (to BPC)

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Zeisel, L