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Ice after injection for 5 minutes

Clinical data demonstrates this clearly, with tirzepatide producing roughly 40% more weight loss than semaglutide while causing less nausea

A similar program for retatrutide is likely, at least during the initial launch period to build market share

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It is currently in advanced clinical development for the management of obesity, type 2 diabetes, and related metabolic disorders

For titration protocols, reconstitution instructions, and dosing calculations, see our guide: Retatrutide Dosing Guide: Full Dosing Chart & Calculator