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Such difference may arise from the subtle changes in pocket residues at 3.37b (H268 for GLP-2R, Q234 for GLP-1R and Q232 for GCGR), 3.40b (V271 for GLP-2R, V237 for GLP-1R and I235 for GCGR) and ECL2 (N334 for GLP-2R, R299 for GLP-1R and N298 for GCGR)

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Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults The comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults were recently investigated in a well-conducted systematic review and network meta-analysis published by Yildiz et al [7], comprising 101 randomised controlled trials covering 20,081 study participants and 68 medications and placebo

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For milder disease, including nondestructive arthritis, enthesitis and axial disease, treatment with an nonsteroidal anti-inflammatory drug (NSAID) may be sufficient