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This outcome was attributed to MOTS-c restoring metabolic balance in muscle tissue (largely via AMPK activation), underscoring its potential for combating age-dependent metabolic decline

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Ashour AA, El-Kamel AH, Abdelmonsif DA, Khalifa HM, Ramadan AA

A 2024 randomized controlled trial involving 60 women aged 4065 applied a 0.1% GHK-Cu cream twice daily for twelve weeks and reported a 31% reduction in wrinkles by imaging analysis, along with 28% improved skin elasticity relative to placebo and a 15.6% increase in collagen density measured by ultrasound

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( d ) change in fat mass and fat free mass from day 5 to 21