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All study protocols and informed consents of human participants were approved by the Institutional Review Board of National Taiwan University Hospital (201507055MINC), and all participants had signed a waiver of informed consent

At a biological level, mononuclear counts increased, granulocytes decreased, and fibroblast, reticulin, and collagen fiber formation increased

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The same study also showed that AtGSTU1 and AtGTU24 genes were significantly altered and involved in susceptibility

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