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The net effect of lactate on redox status is governed by the balance between reducing equivalents of NADH and ROS production, which may differ between normal and cancer cells due to variations in oxidative phosphorylation activity and NADH-processing pathways

The VWD example highlights a broader opportunity across hematology: using healthcare data not only to evaluate treatments but also to improve diagnosis, disease management, and patient outcomes

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(PubMed) The same review warns that systemic administration (IV) may shift melanin production, altering skins natural photoprotection and potentially increasing the risk of UV-induced skin damage or cancer a risk especially relevant in sunny climates

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