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Your body's adaptation phase typically lasts 2-6 weeks, during which nausea and GI discomfort peak around days 3-7 after each dose increase, then gradually decline

however, they are not risk-free

95% CI, 1-1.28) occurred more often in women at high risk for developing breast cancer who received 5 years of tamoxifen therapy (n = 6681) compared with placebo (n = 6707)

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ACS Omega 5 , 1887218886 (2020)