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The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes

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Conclusin La activacin dual de los receptores GLP-1 y GIP aborda mltiples defectos fisiopatolgicos presentes en la DM2, con un mecanismo de accin sinrgico y multimodal que trasciende el control glucmico convencional

They significantly downregulated CHOP and GRP78 expression in diabetic mouse livers, implying a link between hepatic lipid dysregulation and endoplasmic reticulum stress