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irAEs refractory to glucocorticoids may require the administration of a mAb targeting TNF- (i.e., infliximab) to treat certain irAEs such as colitis (136, 237, 245) and pneumonitis (175, 246)

However, dysregulation of necroptosis has been shown to be associated with several diseases and tissue damages including cancer (Dhuriya and Sharma, 2018), ischemia/reperfusion injury (Fulda, 2013), acute pancreatitis (Wang G

1 Aged Muscle Stem Cell Rejuvenation Neelakantan et al., Biochemical Pharmacology (2019) In a follow-up study, the authors tested whether NNMT inhibition could reverse the age-related decline in muscle stem cell (satellite cell) function

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