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doi: 10.1016/j.jep.2024.119256 32 LiuXWuHRenZWangYYangGCongHet al

NAM treatment increased mitochondrial NAD + /NADH ratios and improved mitochondrial membrane potential in human primary cells 115

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The rats were housed separately at 2225C under a 12 h:12 h light cycle

In addition, heparanase expression is high, principally in the glomerulus, 2448 h after LPS treatment, which leads to the glomerular loss of HS and glycosaminoglycans, and is associated with high blood urea nitrogen (BUN), high urinary albumin/creatinine ratio, and glomerular injury (93, 94)