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In colorectal cancer, miR-21 is the target phosphatase, and PTEN is a protein which is overexpressed via curcumin, while in non-small cell lung cancer is under-expressed (Zhang et al., 2010)

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Biological analyses were performed on plasma samples, quantifying total and reduced glutathione, oxidized glutathione and redox ratios using HPLC with colorimetric detection, while behavioral outcomes were assessed weekly through standardized caregiver questionnaires and clinician-rated scales