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#Diabetic Foot Ulcers (DFUs): A Preventable Complication #Foot ulcers occur due to a combination of neuropathy (loss of sensation), poor circulation, and infection risk

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Amphetamines disrupt VMAT2 function and vesicular uptake through a combination of mechanisms: The Weak Base Effect (pH Gradient Collapse) : Amphetamines are lipophilic weak bases (pKa of 9.9) that can readily diffuse across both the plasma and vesicular membranes to accumulate inside synaptic vesicles (Wimalasena 2011)

The Need for Long-Term Studies Most clinical trials for semaglutide focus on short-term outcomes, such as blood sugar control over a few months

In the second trial, the average reductions in events per hour were 29.3 for tirzepatide and 5.5 for the placebo from a starting figure of 49.5 events per hour on average

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