(a) expression was altered more than 4-fold (more than 2 in absolute log2-transformed fold change), (b) p-value from the Students t-test 0.05 between two groups, and (c) false discovery rate (FDR) 0.01
Furthermore, programmed necrosis can also be influenced by ROS, which promote the formation of a stable association between two serine/threonine kinases, namely RIP1 and RIP3, which mediate the complex formation of programmed necrosis (Figure 1) (22, 24, 46, 47)
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