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The incidence of these side effects tends to decrease with continued use and proper dose titration

The liberated p53 then transcription-independently activates the pro-apoptotic protein BAX, thereby triggering the execution phase of apoptosis

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The combination can precipitate severe hyperthermia, muscle rigidity, and even death, so clinicians will avoid MB in patients on serotonergic psychiatric medications (or will stop those medications well in advance of giving MB if its needed emergently)