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Physiol Plant 74:727732

Endnotes: The efficacy estimand represents efficacy had all randomized participants remained on study intervention (with possible dose interruptions and modifications) without initiating prohibited weight management treatments (and glycemic rescue therapy for glycemic endpoints only)

Previous studies have shown that the control level of glycemia is positive with reduced incidence of microvascular diseases, such as diabetic kidney diseases and diabetic retinopathy, although it has a weak relationship with improvement of macrovascular diseases

A BMI of 30 or above qualifies patients for weight loss therapy, as this threshold is associated with obesity-related health risks including type 2 diabetes, hypertension, and cardiovascular disease

Cells were plated on top of the 0.6% Bacto agar layer in glucose and glutamine free DMEM media containing 10 mM glucose and 4 mM glutamine and supplemented with 10% FS and 0.3% Bacto Agar

Mller TD, Blher M, Tschp MH, DiMarchi RD