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So this is my personal opinion, but you will always have segments of the population that are resistant to using pharmaceuticals or want to try natural solutions first, so products like berberine arent going to go away. As for gut health, which has attracted more awareness as GLP-1 drugs have gained traction, SPINS data show sales of probiotic supplements were down 7.6% in the year to October 6

141 Notably, mice with hepatocyte-specific HRD1 deficiency display increased energy expenditure and resistance to high-fat diet-induced obesity and insulin resistance

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