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Due to the cysteine residues of GSH, it can be readily oxidized to glutathione disulfide (GSSG) by electrophilic species directly (e.g., combine with NO to form less reactive S-nitrosoglutathione), or indirectly through enzymatic reactions (e.g., reduce hydrogen peroxide to water by glutathione peroxidase)
This was recently confirmed by Liu et al
Chronic Oxidative Stress: The comprehensive blend of antioxidants, including Vitamin C, Vitamin E, Selenium, and a proprietary carotenoid blend (lutein and zeaxanthin), works synergistically to neutralize free radicals, protecting cellular membranes from ongoing damage caused by a hyperactive immune system
Transl Neurodegener 14(1):10 Trofin D-M et al (2025) Oxidative stress in brain function
Method Literature search strategy Google Scholar and PubMed were searched on various dates between December 2016 and March 2017, ending on 15th March 2017 using the following terms, and variants thereof, and all articles discovered were considered for inclusion: (paracetamol OR acetaminophen hepatotoxicity) AND genetic differences/polymorphisms OR children/neonates/young people/paediatric OR older people/elderly/geriatric OR nutritional state/malnutrition OR body weight/low body weight OR alcohol/alcohol-dependence OR drug interactions/potentiation OR liver disease/chronic liver disease/liver failure
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