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It's one of the fundamental mechanisms of aging

Lower undetectable levels of superoxide dismutase allow oxygen radicals to form in anaerobic bacteria and to inactivate other bacterial enzyme systems

Biomed Res Int 2013:725410 Riesenbeck LM, Bierer S, Hoffmeister I et al (2011) Hypothyroidism correlates with a better prognosis in metastatic renal cancer patients treated with sorafenib or sunitinib

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As you can see in the photos, the blemishes left over from my acne have been reduced, some more than the other, but that has more to do with the intensity of the hyperpigmentation

Note: While B12 is sometimes marketed as an energy booster, strong evidence of benefit in individuals with normal B12 levels is limited