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Given the observed increased risk of colorectal cancer among patients receiving GLP-1 receptor agonists, clinicians should approach long-term prescribing of these agents with careful consideration, particularly in individuals with additional risk factors for colorectal cancer, such as a family history, obesity, inflammatory bowel disease, or long-standing type 2 diabetes

Altevogt, P., Sammar, M., Hser, L

Weight regain after stopping semaglutide or any other GLP-1 receptor agonist is a very common side effect

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GLP-1 and aging: How does it affect longevity