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Ipamorelin is a synthetic five-residue pentapeptide growth-hormone secretagogue developed in the late 1990s by Novo Nordisk as the first selective GHSR-1a (ghrelin receptor) agonist that induced GH release without elevating prolactin, ACTH, cortisol, or aldosterone

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concentration does not increase proportionally with the dose, but rather, increases to a lesser extent due to saturable plasma protein binding