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Indeed, decreased serotonin levels have been reported in HIV (Peltenburg et al., 2018) and TB (Cho et al., 2020) patients

This distinction matters: 503B compounders are pharmaceutical manufacturers and fall under different (stricter) manufacturing rules

Recommended transition protocol: Complete the final tirzepatide dose Wait 7 days Start semaglutide at 0.5 mg (not 0.25 mg, because the patient is already GLP-1 adapted) Escalate to 1.0 mg after 4 weeks, then 1.7 mg, then 2.4 mg Starting at 0.5 mg rather than 0.25 mg reduces the total titration time and is well-tolerated in patients already on tirzepatide

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Children born to mothers with low B12 levels may have excess fat accumulation which in turn can result in higher insulin resistance and risk of T2D and/or CVD in adulthood

Li Y, Glotfelty EJ, Karlsson T, Fortuno LV, Harvey BK, Greig NH