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Dihexa half life (one to three hours) measures the time required for plasma concentrations to decline by 50%, while therapeutic window refers to the duration during which receptor activation drives neuroplasticity changes which extends for hours beyond plasma clearance
We further confirm that the order of authors listed in the manuscript has been approved by all of us
Alzheimers Dement Transl Res Clin Interv 2:141155 Lewis J, Melrose H, Bumcrot D, Hope A, Zehr C, Lincoln S, Braithwaite A, He Z, Ogholikhan S, Hinkle K, Kent C, Toudjarska I, Charisse K, Braich R, Pandey RK, Heckman M, Maraganore DM, Crook J, Farrer MJ (2008) In vivo silencing of alpha-synuclein using naked siRNA
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