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Clinical Studies and Research The current body of research on semaglutide and its effect on eye health focuses primarily on diabetic retinopathy, a condition where the blood vessels in the retina become damaged due to high blood sugar

They are optimal for their insulinotropic effect exclusively when glucose levels are elevated, thereby providing the capacity to decrease plasma glucose while mitigating the risk of hypoglycemia

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These effects were mediated, in part, by activation of GLP-1Rs on GABAergic LDTg neurons that project to the VTA 14