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When exposure occurs as brief, pulsatile cues versus chronic, sustained elevations has opposite consequences for signalling circuits and cumulative damage accrual

Tesamorelin is a growth hormone-releasing hormone (GHRH) analog, not a GLP-1 agonist

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Once a patient reaches their goal weight and stops receiving weekly injections, the weight loss benefits do not continue on their own

While it has shown promise in animal studies, its safety and efficacy in humans have remained uncertain due to a lack of robust clinical trials

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