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Among these, compounds 24 (IC 50 = 0.07 M) and 25 (IC 50 = 0.07 M) (Figure 4) showed exceptional inhibitory activity (101)

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Ipamorelin is a selective ghrelin mimetic that stimulates pulsatile GH secretion without significantly increasing ACTH or cortisol [3] , offering a cleaner GH release profile