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The absence of desaturase enzymes necessary for the interconversion between omega-6 and omega-3 PUFAs renders these two families of PUFAs metabolically distinct and potentially opposed in their physiological functions (52)

doi: 10.1212/01.wnl.0000183063.99107.5c

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But not every patient responds the same way

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Doubling doses can increase the risk of side effects