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Perhaps, novel mechanisms for incretin resistant patients

In clinical studies, both creatine and acetyl-L-carnitine were shown to help the produce energy at the cellular level

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In the late 19th and early 20th centuries, investigators such as Sidney Ringer, who developed Ringers solution, Alexis Hartmann, who added lactate to create lactated Ringers (Hartmanns) solution, and Hartog Jakob Hamburger, whose work contributed to the adoption of 0.9% normal saline, progressively refined fluid composition into the crystalloid solutions used today

Reed J, Kanamarlapudi V, Bain S