Mol Cell Endocrinol 248 , 182191 (2006)
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g ) Previous cryo-EM structures of NMNAT1- and YPEL5-bound CTLH E3 assemblies (EMD-18175 and EMD-18170, respectively) 42 fit with segmented focused-refined maps of relevant modules (EMD-18345 and EMD-18316, respectively) explaining the biochemically defined mode of NMNAT1 targeting: YPEL5 and the oligomeric NMNAT1 substrate are engaged by the overlapping binding sites on the dimeric WDR26 modules
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Real-world observations from clinical practices using semaglutide echo the trial findings: fatigue emerges during dose escalation phases and commonly resolves within one to three weeks of reaching a stable maintenance dose
