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Fifth, the short duration of each treatment phase (1 month) and absence of long-term follow-up preclude conclusions about sustained efficacy, safety, and adherence

5 Disease-Modifying Treatments Despite the rich portfolio of symptomatic approaches to treat the cardinal motor features of PD as well as levodopa-related motor complications there are still major unmet needs in the pharmacological management of progressive motor and non-motor symptoms in the advanced stages of disease [175]

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