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108 With respect to B cells, aging B cells exhibit defects in antibody production and immunoglobulin (Ig) class switching

Methods Mice To induce genetic ablation of the GHR, mice carrying loxP-flanked Ghr alleles 44 were bred either with AgRP-IRES-Cre mouse (Agrp tm1(cre)Lowl /J, The Jackson Laboratory), LepR-IRES-Cre mouse (B6.129-Lepr tm2(cre)Rck /J, The Jackson Laboratory) or Nestin-Cre mouse (B6.Cg-Tg (Nes-cre)1Kln /J, The Jackson Laboratory)

These receptors include, but are not limited to, the Toll-like receptor (TLR) family, the T cell receptor (TCR), and the B cell receptor (BCR)

Journal of Cosmetic Dermatology 4(3):159-165. [doi.org]

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Without enough of the vitamin, the cell may become deformed and unstable