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IL-6 shows a synergistic effect with other mediators of metabolic disease, collectively contributing to the progression of other obesity-associated comorbidities such as CAD and T2DM [64, 69]

Consistency with the treatment plan, including a healthy diet and exercise, is key to achieving and maintaining long-term weight loss

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The insurer reviews the request to confirm the drug is medically necessary, meets their formulary criteria, and is appropriate for the patients diagnosis before theyll agree to cover it

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Screening options include colonoscopy, stool-based testing (FIT or FIT-DNA), and CT colonography in specific circumstances