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Utilizing gradual dose titration protocols, starting with lower doses and incrementally increasing over several weeks, significantly reduces the incidence and severity of these side effects

doi: 10.1210/clinem/dgz140 174 Ten KulveJSVeltmanDJVan BloemendaalLGrootPFCRuhHGBarkhofFet al

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People with diabetes, a history of eating disorders or complex medical conditions are especially vulnerable to ill effects and should not adjust doses without close medical guidance

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

But the weight itself tends to return