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Dysfunctional mitochondria released as components can act as pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), such as mtDNA and reactive oxygen species (ROS), to induce an inflammatory responsemainly in the innate immune systemby activating pattern recognition receptors (PRRs) in pSS (21, 22)
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Thus, the presumed origin of NP tissue, i.e
The more its lowered, the lower the risk of events
This means that as electrons pass from NADH to ubiquinone, protons are pumped into the crista space