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Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets
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It inhibits the production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-12), modulates the polarization of macrophages towards the M2 (anti-inflammatory) phenotype, and stimulates collagen production in models of pulmonary and cutaneous fibrosis
Sometimes they remain local
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