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While direct receptor binding affinity remains an area of ongoing investigation, experimental evidence indicates that AOD 9604 enhances 3-adrenergic receptor expression and signaling capacity in adipose tissue models

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Glp1r expression localizes to the basolateral side of enterocytes in the mucosal layer, and its abundance increases distally (Wismann et al., 2017)

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In the HARMONY-2 (efficacy and safety of once-weekly GLP-1 receptor agonist albiglutide) clinical study, patients were randomized to receive either once-weekly albiglutide (30 mg, titrated up to 50 mg if required for glycemic control) or 10 units of insulin glargine once daily