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The density of bacteria increases from 100 bacteria in the proximal small intestine to 100,000,000 in the distal ileum, and 1,000,000,000,000 in the colon. source Bacterial overgrowth is kept at bay by natural small intestinal defenses

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The Food and Drug Administration said recently it would tighten limits on the ingredients used in compounded GLP-1 drugs, signaling a tougher stance

Exception : Antibiotics prescribed for prophylactic purposes (such as an acne treatment) may be acceptable

JACC Basic Transl Sci (2018) 3:84457

The medications come with detailed inserts that explain how to store the medication properly