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1 Introduction Diabetic kidney disease (DKD) is one of the microvascular complications of diabetes mellitus (DM), imposing a huge economic burden on individuals and public health systems ( 2 Renal tubular changes in DKD Almost 90% of the renal parenchyma consists of renal tubules and tubulointerstitial tissue

Hyperglycemia or Hypoglycemia Inform patients that hypoglycemia is the most common adverse reaction with insulin