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Researchers at Monash University in Melbourne asked whether a discrete structural domain of the hormone might carry the adipose activity by itself

The rationale is that the two medications work through completely different mechanisms, phentermine through norepinephrine release and semaglutide through GLP-1 receptor activation, so they could theoretically complement each other

NNMT is a cytosolic enzyme expressed in adipose tissue, liver, and skeletal muscle

This is not a magic solution

(PubMed) Stabler SP, Lindenbaum J, Allen RH

So rather than try to sue the Chinese companies that were illegally copying their patented peptide, they decided to get their own version onto the market